Dr. Naveen Polavarapu, Senior Consultant, Medical Gastroenterologist, Liver Specialist. Lead Advanced Endoscopic Interventions & Training, Clinical Director, Yashoda Hospitals, Hyderabad shares insights on Millions of people worldwide suffer from Inflammatory Bowel Disease (IBD), which includes Crohn’s disease and ulcerative colitis. IBD causes chronic inflammation, tiredness, diarrhea, and abdominal pain. Dysbiosis, a microbial imbalance in the gut microbiome where dangerous bacteria outnumber helpful ones, is the fundamental cause of immunological overreactions and damage to the gut barrier.
The gut is home to trillions of bacteria, viruses, and fungi that control immunity, preserve digestive health, and even affect mood through the gut-brain axis. Short-chain fatty acids (SCFAs) like butyrate are produced by a variety of microorganisms in healthy people, including Bifidobacterium and Lactobacillus. These SCFAs nourish colon cells and reduce inflammation. This balance is upset by dysbiosis: research indicates that IBD patients have less microbial diversity, with pro-inflammatory species like Escherichia coli increasing and anti-inflammatory species decreasing.
New studies provide avenues for treatment. According to recent trials published in The Lancet, fecal microbiota transplantation (FMT) achieves remission in up to 50% of ulcerative colitis cases by restoring balance through the transfer of healthy donor microorganisms. Diversity is enhanced by probiotics, prebiotics, and synbiotics-live beneficial bacteria combined with their diet. Probiotics reduce flare-ups by 30%, according to a 2024 meta-analysis published in Gastroenterology, whereas dietary therapies including high-fiber Mediterranean diets increase the production of SCFA. Dr. Naveen Polavarapu, provides specialized consultations and care at our center located in BAGDOGRA, WEST BENGAL. To book an appointment, please call [08065906114/08065906179] or book online at –https://www.yashodahospitals.com/
Further advancements in precision medicine include the identification of individual dysbiosis profiles by microbiome sequencing, which directs focused treatments. In preclinical models, antibiotics that specifically target infections in conjunction with postbiotics-microbial byproducts-show promise. We combine these with conventional therapies like biologics at Experts like Doctor at Yashoda Hospitals to produce long-lasting remissions.
A comprehensive transition from dysbiosis to eubiosis (microbial equilibrium) is necessary to overcome IBD. Patients should minimize processed sugars, prioritize fermented foods (yogurt, kimchi), and seek advice from experts for customized regimens. Hope blossoms as research on gut bacteria advances, bringing what was previously terrible suffering closer to controllable wellbeing. Dr. Naveen Polavarapu, will visit Every month to provide specialized consultations and care at our center located in BAGDOGRA, WEST BENGAL. To book an appointment, please call [08065906114 / 08065906179] or book online at –https://www.yashodahospitals.com/
